Non sedating tricyclic antidepressants

The development of newer classes of antidepressants and second-generation antiepileptic drugs has created unprecedented opportunities for the treatment of chronic pain.These drugs modulate pain transmission by interacting with specific neurotransmitters and ion channels.This lead researchers to believe that it may have some antidepressant effects.Upon testing Imipramine, it was found to yield a significant antidepressant response among depressed individuals.

These days they are still used for depression, but are considered a second-line treatment to newer drugs like SSRIs/SNRIs and atypical antidepressants.The efficacy of antidepressants and antiepileptic drugs in the treatment of neuropathic pain is comparable; tolerability also is comparable, but safety and side effect profiles differ.Tricyclic antidepressants are the most cost-effective agents, but second-generation antiepileptic drugs are associated with fewer safety concerns in elderly patients.Antidepressants are prescribed most often for clinical depression and severe cases of depression.Jones, Shinar, and Walsh (2003) provide a breakdown of the subclasses of antidepressants with examples.

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